Ofloxacin vs moxifloxacin eye drops

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We aimed to quantify the penetration of ciprofloxacin, ofloxacin, and moxifloxacin into the cornea and aqueous humor of cadaver eyes. A total of 60 enucleated eyes, not eligible for corneal transplantation, were divided into three groups and immersed in commercial solutions of 0. Whole corneas and samples of aqueous humor were then harvested and frozen, and drug concentrations analyzed by liquid chromatography tandem mass spectrometry. The mean corneal concentration of moxifloxacin was twice as high as ofloxacin, and the latter was twice as high as ciprofloxacin. The mean concentration of moxifloxacin in the aqueous humor was four times higher than the other antibiotics, and the mean concentrations of ciprofloxacin and ofloxacin were statistically similar. The amount of drug that penetrated the anterior chamber after a min immersion was far below the safe limit of endothelial toxicity of each preparation.

Ofloxacin vs moxifloxacin eye drops

Terai , M. Joo , J. Hyon , D. Sinha , T. Abstract: : Purpose: Acute bacterial keratitis is a sight-threatening condition that demands prompt diagnosis and effective therapy. Moxifloxacin, a newer fourth generation ophthalmic fluoroquinolone, has an expanded spectrum of activity including gram positive species, while maintaining excellent gram negative activity. We compared the efficacy of topical moxifloxacin versus other antibiotics and balanced saline solution BSS against experimental keratitis due to Streptococcus pneumoniae and Pseudomonas aeruginosa keratitis in rabbits. Methods: New Zealand white rabbits were randomly divided in two experimental groups: Pneumococcal keratitis and Pseudomonas keratitis. Each group was divided in four subgroups Pseudomonas keratitis study: control BSS , ofloxacin, tobramycin, and moxifloxacin; Pneumococcal keratitis study: control BSS , ofloxacin, penicillin G, and moxifloxacin to compare the drug efficacy with other antibiotic agents and control. Bacterial keratitis models were created with the central corneal intrastromal injection of a ul suspension containing 1 X 10 6 organisms. After the development of infection, topical eye drops were applied onto the affected right eyes every 1 hour for 12 hours. Conclusions: These data demonstrate the excellent in vivo activity of topical moxifloxacin against keratitis due to Streptococcus pneumoniae and Pseudomonas aeruginosa in rabbits. Moxifloxacin is a promising new agent for consideration of initial broad spectrum empiric therapy of bacterial keratitis.

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Official websites use. Share sensitive information only on official, secure websites. Moxifloxacin ophthalmic solution is used to treat bacterial conjunctivitis pink eye; infection of the membrane that covers the outside of the eyeballs and the inside of the eyelids. Moxifloxacin is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infection.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Globally, the alarming increase in the rate of antibiotic AB resistance of bacteria is currently considered one of the 7 major threats to the human race along with terrorism, nuclear proliferation and pollution. Judicious use of AB by physicians in all medical and surgical specialties is essential to limit the extent of resistance to AB. In Europe, Romania ranks among the first in terms of the rate of resistance to AB of the main bacteria involved in eye infections EI. The available ophthalmic topics contain antibiotics from the following classes: aminoglycosides, fluoroquinolones, chloramphenicol, glycopeptides, polymyxins, etc. The increase in the fluoroquinolone resistance rate of the bacteria involved in EI has recently led to the recommendation that, in the absence of the antibiogram, it is best to avoid first-line antibiotic therapy with topical fluoroquinolones alone in keratitis.

Ofloxacin vs moxifloxacin eye drops

Since fluoroquinolone antibiotics were introduced for systemic use in the s, their indications and use have increased rapidly. Recently, topical formulations for the eye and ear have appeared, expanding the options for the treatment of certain bacterial infections. Fluoroquinolones are formulated by adding fluorine and other groups to nalidixic acid. Their bactericidal and bacteriostatic properties result from inhibition of the enzyme DNA gyrase. Bacterial ear infections, such as necrotizing malignant otitis externa and otitis media in ears with intact tympanic membranes, require systemic treatment. However, other forms of infection respond well to topical antibiotics. Two otic preparations of topical fluoroquinolones, ofloxacin 0.

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Moxifloxacin demonstrated far superior penetration into the cornea and anterior chamber of cadaver eyes compared to ciprofloxacin and ofloxacin. Bacterial keratitis models were created with the central corneal intrastromal injection of a ul suspension containing 1 X 10 6 organisms. The limitation of the model is that the cadaver eye does not fully duplicate the living eye, with its tear film, lacrimal drainage, strong epithelial barrier, and slim stroma. Our results also suggest that one should not be concerned with endothelial toxicity when the fluoroquinolones reach the anterior chamber through the cornea. References 1. Afterwards, the organic phase from each sample was transferred to conical glass tubes and the solvent was evaporated to dryness with a gentle stream of nitrogen. The amount of drug that penetrated the anterior chamber after a min immersion was far below the safe limit of endothelial toxicity of each preparation. The collision energy was 25 eV for moxifloxacin and ciprofloxacin, 30 eV for ofloxacin, and 10 eV for the IS. Published online Jul 3. Ratios between the geometric mean concentrations of pairs of antibiotics. In contrast, the difference between ofloxacin and ciprofloxacin in the aqueous humor was not significant Table 3. The mean corneal concentration of moxifloxacin was twice as high as ofloxacin, which was twice as high as ciprofloxacin.

Ofloxacin drops treat bacterial eye infections, including conjunctivitis pink eye and corneal ulcers.

Only 1 eye of each donor was used. Braz J Med Biol Res. In the literature, the percentage is even greater, leaving room for further improvement 4. This feature is available to authenticated users only. Aqueous penetration and biological activity of moxifloxacin 0. By comparing the data of Table 2 to that of Mather et al. Before using moxifloxacin eye drops, tell your doctor and pharmacist if you are allergic to moxifloxacin Avelox, Vigamox , other quinolone antibiotics such as cinoxacin Cinobac not available in the US , ciprofloxacin Cipro, Ciloxan , enoxacin Penetrex not available in the US , gatifloxacin Tequin, Zymar , levofloxacin Levaquin, Quixin, Iquix , lomefloxacin Maxaquin , nalidixic acid NegGram not available in the US , norfloxacin Noroxin , ofloxacin Floxin, Ocuflox , sparfloxacin Zagam , and trovafloxacin and alatrofloxacin combination Trovan not available in the US or any other medications. Table 4. The mean corneal concentration of moxifloxacin was twice as high as ofloxacin, and the latter was twice as high as ciprofloxacin. Weiss RE. Afterwards, the organic phase from each sample was transferred to conical glass tubes and the solvent was evaporated to dryness with a gentle stream of nitrogen. Quantification was performed by multiple reaction monitoring of the precursor ions and their corresponding product ions using a MassLynx data sampling and processing system Micromass, version 4.