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Adults and pediatric patients aged 10 years and older with heterozygous familial hypercholesterolemia HeFH. As an adjunct to other LDL-C-lowering therapies, or alone if such treatments are unavailable, to reduce LDL-C in adults and pediatric patients aged 10 years and older with homozygous familial hypercholesterolemia HoFH.

This medicine is known as atorvastatin. Tea is a popular beverage consumed worldwide. Regularly drinking tea is thought to have many potential health benefits. Read on to find out how tea may help you. Blood tests, imaging tests and more are used to diagnose musculoskeletal disorders. Here's an overview of the tests and procedures used.

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If you are a consumer or patient please visit this version. Warnings and Precautions, Myopathy and Rhabdomyolysis 5. Atorvastatin calcium tablet is an HMG-CoA reductase inhibitor indicated as an adjunct therapy to diet to:. Atorvastatin calcium tablets have not been studied in Fredrickson Types I and V dyslipidemias 1. Tablets: 10, 20 and 40 mg of atorvastatin 3. Myopathy and Rhabdomyolysis: Risks increase when higher doses are used concomitantly with cyclosporine, and strong CYP3A4 inhibitors e. Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported. Atorvastatin calcium therapy should be discontinued if myopathy is diagnosed or suspected 2. IMNM is characterized by: proximal muscle weakness and elevated serum creatine kinase, which persist despite discontinuation of statin treatment; positive anti-HMG CoA reductase antibody; muscle biopsy showing necrotizing myopathy; and improvement with immunosuppressive agents 5. Liver enzyme abnormalities: Persistent elevations in hepatic transaminases can occur. Check liver enzyme tests before initiating therapy and as clinically indicated thereafter 5. A higher incidence of hemorrhagic stroke was seen in patients without CHD but with stroke or TIA within the previous 6 months in the atorvastatin calcium 80 mg group vs. Drug Interactions that may Increase the Risk of Myopathy and Rhabdomyolysis with atorvastatin calcium 2. Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is recommended as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate.

In the majority of pregnancies, statin treatment was initiated prior to pregnancy and was discontinued at some point in the first trimester when pregnancy was identified. Be sure ma white oval pill if you throw medicine away, it is out of the reach of children.

If you are a consumer or patient please visit this version. Tablets: 10 mg; 20 mg; 40 mg; 80 mg of atorvastatin 3. The recommended starting dosage of atorvastatin calcium tablets are 10 mg to 20 mg once daily. The dosage range is 10 mg to 80 mg once daily. The recommended starting dosage of atorvastatin calcium tablets are 10 mg once daily. The dosage range is 10 mg to 20 mg once daily.

This medicine is known as atorvastatin. Tea is a popular beverage consumed worldwide. Regularly drinking tea is thought to have many potential health benefits. Read on to find out how tea may help you. Blood tests, imaging tests and more are used to diagnose musculoskeletal disorders. Here's an overview of the tests and procedures used. Exercise has many benefits for older adults and can help you to live a longer and healthier life.

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If you are a consumer or patient please visit this version. Tablets: 10 mg; 20 mg; 40 mg; 80 mg of atorvastatin 3. The recommended starting dosage of atorvastatin calcium tablets are 10 mg to 20 mg once daily. The dosage range is 10 mg to 80 mg once daily. The recommended starting dosage of atorvastatin calcium tablets are 10 mg once daily.

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If the range does not include 0, this indicates a statistically significant difference. Consider if the benefit of using lipid modifying dosages of niacin concomitantly with atorvastatin outweighs the increased risk of myopathy and rhabdomyolysis. All patients had a clinical diagnosis of HeFH confirmed by genetic analysis if not already confirmed by family history. There have been rare reports of immune-mediated necrotizing myopathy IMNM , an autoimmune myopathy, associated with statin use, including reports of recurrence when the same or a different statin was administered. The proportions of subjects who experienced noncardiovascular death were numerically larger in the atorvastatin calcium 80 mg group than in the atorvastatin calcium 10 mg treatment group. These side effects usually go away if your dose is lowered or atorvastatin calcium tablets are stopped. Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating atorvastatin calcium tablets, and adjust the dosage if necessary. Especially tell your doctor if you take medicines for: your immune system cyclosporine cholesterol gemfibrozil infections erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole birth control pills heart failure digoxin gout colchicine niacin fibrates viruses that treat HIV, AIDS, or hepatitis C anti-virals tipranavir plus ritonavir glecaprevir plus pibrentasvir ledipasvir plus sofosbuvir simeprevir saquinavir plus ritonavir darunavir plus ritonavir fosamprenavir fosamprenavir plus ritonavir elbasvir plus grazoprevir letermovir nelfinavir Ask your doctor or pharmacist for a list of medicines if you are not sure. Discontinue atorvastatin calcium if IMNM is suspected 5. The drugs compared in the studies summarized in the table are not necessarily interchangeable. Eighteen of 30 patients with persistent liver enzyme elevations continued treatment with a reduced dose of atorvastatin calcium. The following important adverse reactions are described below and elsewhere in the labeling: Myopathy and Rhabdomyolysis [see Warnings and Precautions 5. Distribution Mean volume of distribution of atorvastatin is approximately liters.

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It is especially important to lower your cholesterol if you have heart disease, smoke, have diabetes or high blood pressure, are older, or if heart disease starts early in your family. Your doctor may start you on a cholesterol lowering diet before giving you atorvastatin calcium tablets. Adults and pediatric patients aged 10 years and older with heterozygous familial hypercholesterolemia HeFH. In most cases, these changes appeared soon after initiation, were transient, were not accompanied by symptoms, and resolved or improved on continued therapy or after a brief interruption in therapy. Instruct patients to promptly report any unexplained muscle pain, tenderness or weakness particularly if accompanied by malaise or fever [see Warnings and Precautions 5. Consider if the benefit of using fibrates concomitantly with atorvastatin outweighs the increased risk of myopathy and rhabdomyolysis. The primary endpoint was the occurrence of any of the major cardiovascular events: myocardial infarction, acute CHD death, unstable angina, coronary revascularization, or stroke. Inform patients that the risk is also increased when taking certain types of medication or consuming large quantities of grapefruit juice and they should discuss all medication, both prescription and over the counter, with their healthcare provider. General information about atorvastatin calcium tablets Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. In vitro studies suggest the importance of atorvastatin calcium metabolism by cytochrome P 3A4, consistent with increased plasma concentrations of atorvastatin calcium in humans following co-administration with erythromycin, a known inhibitor of this isozyme [see Drug Interactions 7. Five of the 29 patients had absent LDL-receptor function. Tablets: 10, 20 and 40 mg of atorvastatin 3. Consider if the benefit of use of these products outweighs the increased risk of myopathy and rhabdomyolysis [ see Drug Interaction s 7. Increases in liver enzyme tests in other patients were not associated with jaundice or other clinical signs or symptoms. For the most recent prescribing information, please visit www.