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If you are a consumer or patient please visit this version. Methocarbamol Tablets, USP, a carbamate derivative of guaifenesin, is a central nervous system CNS depressant with sedative and musculoskeletal relaxant properties. The chemical name of methocarbamol is 3- 2-methoxyphenoxy -1,2-propanediol 1-carbamate and has the empirical formula C 11 H 15 NO 5. Its molecular weight is The structural formula is shown below.

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Hepatobiliary: abnormal liver function tests, hepatitis some cases have been fatal Hemic and Lymphatic: eosinophilia, leucopenia, granulocytopenia, white oblong pill 500, hemolytic anemia, aplastic anemia M etabolic and Nutritional: hyperglycemia, hypoglycemia Nervous System: depression, dream abnormalities, insomnia, malaise, myalgia, muscle weakness, aseptic meningitis, cognitive dysfunction, convulsions R espiratory: eosinophilic pneumonitis, asthma Dermatologic: alopecia, urticaria, toxic epidermal necrolysis, erythema multiforme, erythema nodosum, fixed drug white oblong pill 500, lichen planus, pustular reaction, systemic lupus erythematoses, bullous reactions, including Stevens-Johnson syndrome, photosensitive dermatitis, photosensitivity reactions, including rare cases resembling porphyria cutanea tarda pseudoporphyria lined synonym epidermolysis bullosa. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

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If you are a consumer or patient please visit this version. Cardiovascular Thrombotic Events. These events can occur at any time during use and without warning symptoms. Nabumetone is a naphthylalkanone designated chemically as 4- 6-methoxy naphthalenyl butanone. It has the following structure:. Nabumetone, USP is a white or almost white crystalline substance with a molecular weight of It is nonacidic, freely soluble in acetone, sparingly soluble in alcohol and in methanol, practically insoluble in water. It has an n-octanol:phosphate buffer partition coefficient of at pH 7. Each tablet, for oral administration contains either mg or mg of nabumetone, USP.

White oblong pill 500

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Intervention: Monitor patients with concomitant use of naproxen with anticoagulants e. Get emergency help right away if you get any of the following symptoms:. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. If you are a consumer or patient please visit this version. Safety and effectiveness of methocarbamol in pediatric patients below the age of 16 have not been established. Body as a whole: Anaphylactic reaction, angioneurotic edema, fever, headache Cardiovascular system: Bradycardia, flushing, hypotension, syncope, thrombophlebitis Digestive system: Dyspepsia, jaundice including cholestatic jaundice , nausea and vomiting Hemic and lymphatic system: Leukopenia Immune system: Hypersensitivity reactions Nervous system: Amnesia, confusion, diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures including grand mal , vertigo Skin and special senses: Blurred vision, conjunctivitis, nasal congestion, metallic taste, pruritus, rash, urticaria. A b s orp tion. Steady-state levels of naproxen are reached in 4 to 5 days, and the degree of naproxen accumulation is consistent with this half-life. These limitations preclude establishing a reliable estimate of the risk of adverse fetal and neonatal outcomes with maternal NSAID use. If you are a consumer or patient please visit this version. Safety and effectiveness in pediatric patients below the age of 2 years have not been established. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents. If these occur, instruct patients to stop naproxen and seek immediate medical therapy [see Warnings and Precautions 5.

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In animal reproduction studies in rats, rabbits, and mice no evidence of teratogenicity or fetal harm when naproxen was administered during the period of organogenesis at doses 0. The pharmacological activity of naproxen in reducing inflammation, and possibly fever, may diminish the utility of diagnostic signs in detecting infections. Digoxin Clinical Impact: The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Patients taking angiotensin converting enzyme ACE inhibitors, thiazide diuretics, or loop diuretics may have impaired response to these therapies when taking NSAIDs [see Drug Interactions 7 ]. Methocarbamol may cause a color interference in certain screening tests for 5-hydroxyindoleacetic acid 5-HIAA using nitrosonaphthol reagent and in screening tests for urinary vanillylmandelic acid VMA using the Gitlow method. The clinical significance of this finding is unclear, although it is possible that the increase in free naproxen concentration could be associated with an increase in the rate of adverse events per a given dosage in some elderly patients. General: abnormal renal function, anemia, elevated liver enzymes, increased bleeding time, rashes. General information about the safe and effective use of NSAIDs Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Safety and effectiveness of methocarbamol in pediatric patients below the age of 16 have not been established. Inform patients about the signs and symptoms of serious skin reactions, and to discontinue the use of naproxen at the first appearance of skin rash or any other sign of hypersensitivity. Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been associated with cases of fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment. They are available as follows:. Other albumin-bound drugs Clinical Impact: Naproxen is highly bound to plasma albumin; it thus has a theoretical potential for interaction with other albumin-bound drugs such as coumarin-type anticoagulants, sulphonylureas, hydantoins, other NSAIDs, and aspirin.