Stilbene

Federal government websites often end in. The site stilbene secure. BoxKuopio, Finland.

Classified as a diarylethene , it features a central ethylene moiety with one phenyl group substituent on each end of the carbon—carbon double bond. It has an E stereochemistry, meaning that the phenyl groups are located on opposite sides of the double bond, the opposite of its geometric isomer , cis -stilbene. Trans -stilbene occurs as a white crystalline solid at room temperature and is highly soluble in organic solvents. It can be converted to cis -stilbene photochemically , and further reacted to produce phenanthrene. Stilbene was discovered in by the French chemist Auguste Laurent. Stilbene exists as two possible stereoisomers. One is trans -1,2-diphenylethylene, called E -stilbene or trans -stilbene.

Stilbene

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Immunosenescence in vertebrates and invertebrates. Zhang X. Experiments in mice models of ADs have indicated that polyphenol based diets can alleviate stilbene spatial working memory deficit and some other cognitive traits, stilbene.

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Federal government websites often end in. The site is secure. Stilbene and its derivatives belong to the group of biologically active compounds. Some derivatives occur naturally in various plant species, while others are obtained by synthesis. Resveratrol is one of the best-known stilbene derivatives.

Stilbene

Federal government websites often end in. The site is secure. Box , Kuopio, Finland. Numerous studies have highlighted the key roles of oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, age-related macular degeneration AMD , and Alzheimer's disease AD. In aging cells, the natural antioxidant capacity decreases and the overall efficiency of reparative systems against cell damage becomes impaired. There is convincing data that stilbene compounds, a diverse group of natural defence phenolics, abundant in grapes, berries, and conifer bark waste, may confer a protective effect against aging-related diseases. This review highlights recent data helping to clarify the molecular mechanisms involved in the stilbene-mediated protection against oxidative stress. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed. Aging is one of the major risk factors for a wide range of chronic, metabolic, and neurodegenerative diseases. During the course of aging, reactive oxygen species ROS cause increasing oxidative stress in cells leading to oxidative damage and to the induction of inflammatory cascades Figure 1.

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Rejuvenation Research. It can be converted to cis -stilbene photochemically , and further reacted to produce phenanthrene. Moss R. A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 OCT-1 The Journal of Biological Chemistry. Layfield R. In rats, resveratrol may mediate body-fat reduction also via the modulation of thermogenesis as UCP protein was increasingly expressed after resveratrol treatment in the important thermogenic levels [ ]. Gene expression patterns of two human tissue samples subcutaneous abdominal adipose tissue SAT and visceral adipose tissue VAT derived from nonobese and class III obese subjects were recently analyzed [ ]. Bertelli A. Polyphenols or polyphenol metabolites produced in the body mediate their protective action via several mechanisms and different pathways that are currently under intensive study. It has therefore been postulated that the inhibition of PDE4 activity via bioactive compounds may protect from or ameliorate the symptoms of metabolic diseases associated with aging such as T2D. Wang J. Di Liberto V. Modulation of Other Pathways Underlying the Antioxidant Defence Systems There is growing data that polyphenols have alternative molecular targets and this complicates elucidation of their role in cellular physiology and pathophysiology. E -Stilbene itself is of little value, but it is a precursor to other derivatives used as dyes , optical brighteners , phosphors , and scintillators.

Stilbenes are naturally occurring compounds with valuable properties such as antioxidant, anticancer, anti-diabetic, and anti-hypercholesterolemia activities.

The Journal of Neuroscience. Weinheim: Wiley-VCH. Only at very high doses used in some human studies such as repeated doses at 2. The activation of autophagy is concurrently aided by AMPK mediated inhibition of mammalian target of rapamycin mTOR , a known suppressor of autophagy [ ]. Annals of Neurology. Qin S. Chung J. For example, Nrf2 knockout mouse displays progressive degeneration of retina see Section 5. Furthermore, antioxidant defence systems against oxidative stress deteriorate during aging and many antioxidant phase II genes are upregulated only marginally or may even be downregulated. The Journal of Biological Chemistry. Nature Reviews Molecular Cell Biology. Molecular Aspects of Medicine. Rimando A. Takikawa M.