Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B[3] [4] dihydrotanshinonesalvia miltiorrhiza, miltirone[5] tanshinone Iand tanshinone IIA.

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects.

Salvia miltiorrhiza

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. Salvia miltiorrhiza Bunge, also known as red sage or Danshen Chinese Pinyin name , is a perennial plant Fig. Following this first record, S. In the textbooks of academic TCM, S.

Compound Danshen Salvia miltiorrhiza dripping pill for coronary heart disease: an overview of systematic reviews.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge S. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. The findings on multi-functional properties of S.

Salvia miltiorrhiza

Salvia miltiorrhiza Bunge is the source species of Danshen listed in Chinese Pharmacopoeia edition. Currently, the germplasm of S. Attempts have been made to use molecular markers and DNA barcoding in evaluating the genetic diversity and species identification of medicinal Danshen materials.

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MI exerts multiple insults in myocardium, frequently accompanied by reactive oxygen species ROS generation, intracellular calcium overload, myocardial apoptosis, endothelial dysfunction, enhanced adhesion of leukocytes and mast cell degranulation [ 71 , , ]. Ann Pharmacother. Korematsu K, Goto S, Nagahiro S, Ushio Y: Microglial response to transient focal cerebral ischemia: an immunochemical study on the rat cerebral cortex using anti-phosphotysine antibody. Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism. Second, S. Qian Q. The revealed pathways targeted by S. Cardiovascular effects of Danshen. The extracts of S. Yang P. Biotechnol Biotechnol Equip. Ischemic cardiovascular disease 74 1 month. Clinical study on compound danshen dropping pill combined with betaloc piecefor the treatment of coronary heart disease. In short, S. Guan X.

Federal government websites often end in. The site is secure.

Compound Danshen dripping pills Self control Cardiovascular diseases Observe clinical symptoms and treatment efficacy. Thus, S. Ineffective 1. Jin Y. Now, several provinces in China start to domestically plant S. Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling. The Cochrane Database of Systematic Reviews. BMC Complement. However, these side effects are relieved when patients stop taking the medications [ 16 ]. Unstable angina pectoris 80 14 days. Raffetto J.