Phenanthrol

Insecticides and metabolites, Additional pesticides phenanthrol metabolites, phenanthrol, TRC, Carbonyl compounds, Insecticides and metabolites, Additional pesticides and metabolites. Or continue browsing without access to favourites or pricing.

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Phenanthrol

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Mutations in TRPM4 have been reported in patients with different types of cardiac conduction defects. It is also linked to immune response and cancers, but the associated molecular mechanisms are still unclear. Thus far, 9-phenanthrol is the most common pharmacological compound used to investigate TRPM4 function. Mouse models are essential to investigate ion channel physiology and chemical compound efficacy. NBA inhibited both human and mouse TRPM4 currents when applied intracellularly and extracellularly using excised membrane patches. Instead, its increased mouse TRPM4 current at negative holding potentials. Application of 9-phenanthrol, both intracellularly and extracellularly, inhibited human TRPM4. For mouse TRPM4, 9-phenanthrol perfusion led to opposite effects depending on the site of application.

Phenanthrol

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