Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetronondansetron drug interactions, known under the brand name Zofranis a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapytreatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral ondansetron drug interactions, and an orally-disintegrating tablet.

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Ondansetron drug interactions

Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. The purpose of this study was to evaluate the potential pharmacokinetic interactions between ondansetron and high-dose alkylating agent chemotherapy. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. All patients received lorazepam every 4 h. A group of 75 matched historical controls had received a continuous infusion of prochlorperazine with lorazepam. Pharmacokinetic monitoring of each drug used in the high-dose chemotherapy regimen was conducted. Results: Median AUCs of cyclophosphamide in patients receiving ondansetron Patients treated with ondansetron displayed a higher frequency of headaches than the controls. Conclusion: Ondansetron altered the systemic exposure to cyclophosphamide when these agents were administered concomitantly. Ondansetron did not substantially improve overall emetic control when used alone but may improve control in combination with prochlorperazine.

Both Ondansetron and Vortioxetine can increase the risk of serotonin syndrome. The area postrema, located on the fourth ventricle floor, contains the "chemoreceptor trigger zone, ondansetron drug interactions. Concomitant use of ondansetron and apomorphine can lead to profound hypotension and loss of consciousness, with ondansetron enhancing the hypotensive effects of apomorphine.

Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet.

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Amphotericin B is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. A case report describes an ondansetron overdose in an infant presenting with seizures, QTc prolongation, hepatotoxicity, and serotonin syndrome. Also tell them about any supplements you take. Similar articles in PubMed. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. To take the Zofran ODT : orally disintegrating tablet. Both Ondansetron and Methadone can increase the risk of serotonin syndrome. Selective serotonin reuptake inhibitors , in addition to sertraline, include:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. The safety and effectiveness of using this medication to treat nausea and vomiting caused by radiation or surgery have not been determined for children less than 18 years of age.

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ISRN Oncol. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. CNS Drugs. Epub Oct Both Ondansetron and Toremifene prolong the QT interval. Future randomized studies are needed to delineate the effect of ondansetron on the disposition of the active cyclophosphamide metabolites so that clinical implications can be addressed. Both Ondansetron and Voriconazole prolong the QT interval. Both Ondansetron and Fenfluramine can increase the risk of serotonin syndrome. Medications can also cause acquired long QT syndrome. Coma and death are possible. The combination of metformin with ondansetron may increase the blood levels of metformin, such that individuals on concomitant therapy must be monitored for metformin effects or toxicities.