Norleucine

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A systematic name for this compound is 2-aminohexanoic acid. It is a white, water-soluble solid. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. Its biosynthesis has been examined. The incorporation of Nle into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase.

Norleucine

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Medium-chain fatty acids Amino fatty acids Amino acids Monocarboxylic acids and derivatives Norleucine acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds. Cancer Metab, norleucine. Interactive image.

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We are working on a new version of ChemSpider — if you want to try the new interface go to beta. Simple Structure Advanced History. Comment on this record. Featured data source. S Aminocaproic acid. S amino-Hexanoi c acid. S Aminohexanoic acid. S -a-Aminocaproic acid. S -Aminohexanoic a cid.

Norleucine

Federal government websites often end in. The site is secure. The broadly active glutamine antagonist 6-diazooxo-L-norleucine DON has been studied for sixty years as a potential anticancer therapeutic. Clinical studies of DON in the s using low daily doses suggested antitumor activity, but later phase I and II trials of DON given intermittently at high doses were hampered by dose-limiting nausea and vomiting. Further clinical development of DON was abandoned. Recently the recognition that multiple tumor types are glutamine dependent has renewed interest in metabolic inhibitors such as DON. Here we describe the prior experience with DON in humans. Evaluation of past studies suggests that the major impediments to successful clinical use included unacceptable gastrointestinal GI toxicities, inappropriate dosing schedules for a metabolic inhibitor, and lack of targeted patient selection. When these prodrugs are administered in a low daily dosing regimen, appropriate for metabolic inhibition, they are robustly effective without significant toxicity.

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Belongs to the class of organic compounds known as l-alpha-amino acids. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Y verify what is Y N? List of abiotic amino acids. Pure and Applied Chemistry. In Miller—Urey experiments probing prebiotic synthesis of amino acids, norleucine and especially norvaline are formed. Kokai Tokkyo Koho , 4 pp. L-Norleucine exists in all eukaryotes, ranging from yeast to humans. Wikimedia Commons. Gmelin Reference.

A systematic name for this compound is 2-aminohexanoic acid.

PMID It is a white, water-soluble solid. Organic compounds. Fermentative production of L-norleucine. L-Norleucine is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Property Value Source Water Solubility. Belongs to the class of organic compounds known as l-alpha-amino acids. Auflage, Georg Thieme Verlag, Stuttgart Aminolevulinic acid 5-ALA Cystine. Medium-chain fatty acids Amino fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds. An unnatural amino acid that is used experimentally to study protein structure and function. It is nearly isosteric with methionine , even though it does not contain sulfur.