Milk thistle zararları

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How to use: For adults, it is recommended to take 1 capsule 2 times a day after meals and dissolve 1 sachet in a glass ml of water once a day and take after meals. Recommended consumption date and lot number are on the packaging. Store at room temperature, protect from heat and light. Additional Information: Do not exceed the recommended daily dose. Supplements cannot replace a normal diet.

Milk thistle zararları

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Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats.

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One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Silymarin is believed to have antioxidant properties. Milk thistle is sold as an oral capsule, tablet and liquid extract. People mainly use the supplement to treat liver conditions. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. There is also concern that milk thistle might affect estrogen levels. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction anaphylaxis. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums.

Milk thistle zararları

Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Other benefits include promoting healthy digestive function, increasing bile production , decreasing inflammation and soothing the mucous membranes throughout the body.

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Evid Based Complement Alternat Med. Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells. Oxidants in chronic kidney disease. Menning, The psychosocial impact of infertility. Agents that prevent or decrease hepatocyte death due to free fatty acids can be a potential medication for NAFLD In mouse model of alcoholic liver diseases that oxidative stress and inflammation were the main causes of the pathogenesis, silymarin was observed to pose hepatoprotective effects by producing the tumor necrosis factor TNF and decreasing the serum alanine aminotransferase ALT activity, which inhibits lipid peroxidation, and increases the intracellular GSH content 6. Davies K J. Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation. Nutr Metab. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: Role of multidrug resistance-associated protein 2 Abcc2 Drug Metab Dispos.

Milk thistle Silybum marianum is a herb loaded with antioxidants and is known for its anti-inflammatory properties.

The available forms of Milk thistle are capsules, tablet, tincture and intravenous solution. Additional Information: Do not exceed the recommended daily dose. As there was not significant toxicity of silymarin reported in human studies, this substance can be used with anti-tuberculosis drugs as a supplement added to the diet Metodiewa D, Koska C. Epub Jun Silymarin effects have also been indicated in various illnesses of different organs such as prostate, lungs, CNS, kidneys, pancreas, and skin 9. While apoptosis is induced by p53 through activating pro-apoptotic genes, levels of p53 increase by silymarin treatment in a dose dependently manner which leads to cytochrome C release, activating many pro-apoptotic genes such as APAF-1 and caspase The possible known mechanisms of action of silymarin protection are blockade and adjustment of cell transporters, p-glycoprotein, estrogenic and nuclear receptors. Davies K J. Silybinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells. Carcinoma Clin Cancer Res. Teede, et al. Hence, it can be used as a promising medication in complementary medicine.