J exp med

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Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. The paramount objective of WJEM is to showcase and promote distinguished research in the field of experimental medicine, to help advance development of this field. Advanced Search.

J exp med

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Although the journal was adopted by the Rockefeller Institute as a venue for publication of the institute's own research, it also accepted submissions from outside. Even in the early years, more than half of the papers published in the journal came from external labs. An online archive of articles back to is available in text and PDF formats material from and earlier is only available in PDF. Material over six months old is freely accessible and access to all papers is also provided free of charge to developing countries. All content is also deposited in PubMed Central , where it is available to the public six months after publication.

Case Control Study. Copyright to articles remains with the authors and third parties may re-use content after 6 months under the terms of a Creative Commons Attribution-Noncommercial-Share Alike 3.

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J exp med

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses.

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Zhang et al. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. Submit Your Research. Rockefeller University Press United States. Tools Tools. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. Research on nanosciences involvement in pharmaceutical education should be reinforced. Core Tip. Risk factors for hydroxychloroquine-induced arrhythmia. Read Edit View history. Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis.

Journal of Experimental Medicine JEM is a broad journal that publishes papers providing novel conceptual insight into immunology, cancer biology, vascular biology, microbial pathogenesis, neuroscience, and stem cell biology.

Read Edit View history. Manage Email Alerts. Impact factor. Review Cancer Focus. IL promotes skin autoinflammation. March 13 World J Exp Med 13 5 : Contents Volume 13 Issue 5 December 20, Autoinflammation is marked by IL-1 cytokine overexpression and excessive infiltration by neutrophils. February 28