Gudrun göhring

Genes, Chromosomes and Cancer54 12 In eosinophilia-associated myeloproliferative neoplasms MPN-eoconstitutive activation of protein tyrosine kinases TK as consequence of translocations, inversions, or insertions and creation of TK fusion genes is recurrently observed. The fusion proteins identified gudrun göhring 5?

CML is a rare form of leukemia among children and adolescents, but one of the common hematological diseases in older age. A number of clinical findings in pediatric CML suggest differences of leukemia cell or host biology compared with CML in adults. Aim of the clinical CMLpaed registry and the accompanying research projects is to understand the age dependent molecular and cellular features of the disease and their impact on the clinical management. J Cell Mol Med. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Suttorp M, et al.

Gudrun göhring

Nat Commun ;13 1 DOI: Epub Mar Cell Dev. Epub Jan Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology ;14 1 Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells. Gene Ther ;24 5 Sci Rep ;7 1 Eur J Haematol ;98 5 Stem Cell Res ; Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Adv ;1 14 Science ; DOI:

Skip to main content, gudrun göhring. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Schnittger, Susanne.

T1 - Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome. N2 - To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Structurally complex constitutes a new definition of complex karyotype characterized by more than or equal to 3 chromosomal aberrations, including at least one structural aberration. Five-year overall survival in patients with more than or equal to 3 clonal aberrations, which were not structurally complex, did not differ from that observed in patients with normal karyotype. The presence of a structurally complex karyotype was the strongest independent prognostic marker predicting poor outcome in children with advanced myelodysplastic syndrome. AB - To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity.

Blood ; Supplement 1 : — Introduction: We evaluated low coverage whole genome sequencing WGS of acute myeloid leukemia AML patients using long read Oxford Nanopore Technology ONTseq for karyotyping and compared the results and the frequency of patients with myelodysplasia-related cytogenetic abnormalities according to previous and current AML classifications with conventional cytogenetics CG. Ten samples were sequenced independently in two different laboratories. Fifty samples were sequenced prospectively from newly diagnosed de novo AML patients. Analysis of the ten duplicate samples established a high reproducibility of ONTseq. Two of these 7 discrepant patients had translocations as their sole cytogenetic abnormality [t 8;21 and t 9;11 ], which cannot be detected by low coverage genome ONTseq. Patients with chromosomal abnormalities had a median of 29 range and 30 range chromosomal bands with CNVs according to ONTseq and CG, respectively. Fifty of the patients were sequenced prospectively at time of diagnosis. The median age of these patients was 70 years range and all patients had de novo AML. The median time for library preparation for prospectively analyzed patients was hours, for ONTseq 24 hours and for bioinformatic analysis hours.

Gudrun göhring

Blood ; 4 : — IDH2 mutations of amino acid or could be identified in This study was registered at www. In an attempt to discover unknown molecular alterations in patients with acute myeloid leukemia AML , whole genome sequencing was performed on AML patients. In the present study, we performed a comprehensive analysis of mutations occurring in exon 4 of IDH2 including both codons R and R in patients with CN-AML in the context of other known prognostic markers. These patients were intensively treated with a uniform protocol in 2 consecutive multicenter trials.

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Cite Icon Cite. In summary, of the 30 monosomal karyotypes with at least one autosomal monosomy and one or more structural aberrations, 19 fulfilled the definition of a structurally complex karyotype. Patients classified as monosomal karyotype only in panel B are now included in the group of monosomy 7 with or without additional aberrations or other karyotypes. Naumann, Nicole. Blood 19 : — This repository has been built using EPrints software , developed at the University of Southampton, but available to everyone to use. View Large. We use cookies to ensure that we give you the best experience on our website. AB - To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in Childhood studies was evaluated with regard to karyotypic complexity. Contribution: G. Nat Commun. Retrovirology ;14 1 First Edition Alert. Skip to main content.

Philadelphia chromosome-positive chronic myeloid leukemia CML is cytogenetically characterized by the classic translocation t 9;22 q34;q11 , whereas additional non-Philadelphia aberrations nPhAs have been studied extensively in adult patients with CML, knowledge on nPhAs in pediatric patients with CML is still sparse.

Jawhar, Mohamad. All patients younger than 18 years with adequate cytogenetic studies and advanced MDS ie, refractory anemia with excess blasts or refractory anemia with excess blasts in transformation , 9 , 10 enrolled in studies EWOG-MDS 98 www. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. View Metrics. Cell Biol Int. Cell Stem Cell. Author: Andreas Reiter. Monika Trebo , Monika Trebo. Results and discussion. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.