Free radic res
Free radicals and other reactive oxygen species ROS are constantly formed in the human body. Free-radical mechanisms have been implicated in free radic res pathology of several human diseases, including cancer, atherosclerosis, malaria, and rheumatoid arthritis and neurodegenerative diseases.
Federal government websites often end in. The site is secure. Free radicals and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. They are produced either from normal cell metabolisms in situ or from external sources pollution, cigarette smoke, radiation, medication. When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. This mini-review deals with the taxonomy, the mechanisms of formation and catabolism of the free radicals, it examines their beneficial and deleterious effects on cellular activities, it highlights the potential role of the antioxidants in preventing and repairing damages caused by oxidative stress, and it discusses the antioxidant supplementation in health maintenance.
Free radic res
Free Radical Research , formerly Free Radical Research Communications , is an academic journal that publishes research papers, hypotheses, and reviews on free radicals , redox signaling , antioxidants , and oxidative damage. It is published by Informa Healthcare. Free Radical Research publishes 12 issues per year in simultaneous print and online editions. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. Download as PDF Printable version. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources.
Plant Cell Physiol. J Exp Bot.
Federal government websites often end in. The site is secure. In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases.
Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 CoQ10 are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an important antioxidant. Because of its hydrophobicity and large molecular weight, absorption of dietary CoQ10 is slow and limited. In the case of dietary supplements, solubilized CoQ10 formulations show enhanced bioavailability. The T max is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma CoQ10 range from 0. With CoQ10 supplements there is reasonable correlation between increase in plasma CoQ10 and ingested dose up to a certain point. Animal data show that CoQ10 in large doses is taken up by all tissues including heart and brain mitochondria.
Free radic res
Objectives: The goal of our study was to investigate the associations of oxidized LDL apoB aldehyde-modified form and acute phase proteins fibrinogen, CRP with acute ischemic stroke severity and outcome. Materials and methods: The study included 61 ischemic stroke patients and 64 controls. Strokes were subtyped according to TOAST criteria, the severity and outcome of stroke at 1 year were measured. Results: The mean triglyceride, fibrinogen, CRP and glucose values were significantly higher among cases. The median oxLDL value for patients with large artery atherosclerosis LAA type of stroke was significantly higher than for other subtypes. The oxLDL values did not correlate with age, stroke severity and outcome. Conclusions: Inflammatory markers fibrinogen and CRP predicted the stroke severity and outcome whereas elevation of oxLDL levels did not. Our data refer to possibility that there may exist some links between the LAA subtype of stroke and elevated oxLDL apoB aldehyde-modified form. Abstract Objectives: The goal of our study was to investigate the associations of oxidized LDL apoB aldehyde-modified form and acute phase proteins fibrinogen, CRP with acute ischemic stroke severity and outcome. Publication types Research Support, Non-U.
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The development of cancer in humans is a complex process including cellular and molecular changes mediated by diverse endogenous and exogenous stimuli. When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. Journal homepage. Google Scholar Stampfer, M. The third line of defense is the repair and de novo antioxidants. Lipid Mediat. Greenberg, E. Hogg, B. Dennis, W. Clemens, M.
Acute kidney injury AKI is a major kidney disease associated with poor clinical outcomes. Oxidative stress is predominantly involved in the pathogenesis of AKI. Autophagy and the Keap1-Nrf2 signalling pathway are both involved in the oxidative-stress response.
These by-products are generally reactive oxygen species ROS as well as reactive nitrogen species RNS that result from the cellular redox process. Selenium deficiency can occur in patients on total parenteral nutrition TPN and in patients with gastrointestinal disorders. Kato, K. For the preventive way, an antioxidant enzyme like superoxide dismutase, catalase and glutathione peroxidase can prevent oxidation by reducing the rate of chain initiation, e. Apoptosis in neurodegenerative disorders. Lipid Res. Salgo, M. Farooq, N. Article Google Scholar Huie, R. Show this widget in your own website. Under the action of free radicals, the crystalline proteins in the lens can cross-link and aggregate, leading to the formation of cataracts
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