Euronetwork
Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference euronetwork the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was euronetwork. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival, euronetwork.
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Euronetwork
Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms.
Patients Patients were recruited from January 1, euronetwork, to December 31,
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Euronetwork
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Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies. Finding 2 patients with Parkinson disease one with progressive supranuclear palsy and the other with dystonia might again be a chance association. Privacy Policy Terms of Use. Other frequent findings were joint position alterations All other antibodies had frequencies below Setting: Twenty European centers. You can change your cookie settings at any time. Data were centrally reviewed, and all generated queries were processed at an independent statistical and quality assessment center Mario Negri Institute of Pharmacological Research, Milan, Italy. Privacy Policy. A remarkable finding was the poor prognosis of patients with dysautonomia; a tumour was found in 37 out of 51 cases and in 28 of these the diagnosis followed the neurological syndrome with a median time of 4. Recommended diagnostic criteria for paraneoplastic neurological syndromes. Cookies on Companies House services We use some essential cookies to make our services work. Drafting of the manuscript : Giometto, Grisold, and Vitaliani. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms.
Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system.
Save your search. Techniques used to detect these antibodies varied according to the different laboratories but were essentially based on immunohistochemistry, Western blotting, and the use of recombinant onconeural proteins. Analyses were performed using commercially available statistical software SAS, version 9. While the database was not designed for the conduction of epidemiological studies, the data is considered to represent the relative prevalence of each syndrome. Although similar results have been described in patients with Tr antibodies, 15 this is a relevant prognostic finding. Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Infrequently, other tumors such as of the prostate, thymus, and testis were observed. It is unknown why no antibodies were found in many of our patients and could be related to unidentified antibodies or to the presence of surface antibodies. The lack of extensive clinical and epidemiologic studies on these rare disorders prompted establishment of the PNS Euronetwork by 20 consortium members from 11 European countries. Conclusion The study results confirm that PNS influences oncologic patient survival. View Large Download. Privacy Policy. Setting: Twenty European centers. Confirmation statement Next statement date 14 December due by 28 December Last statement dated 14 December
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