Dppc full form

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Federal government websites often end in. The site is secure. Phosphatidylcholine PC is the major phospholipid of pulmonary surfactant and it is hypothesized that PC and its subspecies modulate the functions of alveolar macrophages. The most abundant of these subspecies is dipalmitoylphosphatidylcholine DPPC. This study was undertaken to determine the effect of PC on monocyte function using a human monocytic cell line, MonoMac-6 MM6.

Dppc full form

Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. By adsorbing to the air-water interface of alveoli , with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine DPPC , reduces surface tension. As a medication, pulmonary surfactant is on the WHO Model List of Essential Medicines , the most important medications needed in a basic health system. Alveoli can be compared to gas in water, as the alveoli are wet and surround a central air space. The surface tension acts at the air-water interface and tends to make the bubble smaller by decreasing the surface area of the interface. Compliance is the ability of lungs and thorax to expand. Lung compliance is defined as the volume change per unit of pressure change across the lung. This difference in inflation and deflation volumes at a given pressure is called hysteresis and is due to the air-water surface tension that occurs at the beginning of inflation. However, surfactant decreases the alveolar surface tension , as seen in cases of premature infants with infant respiratory distress syndrome. Pulmonary surfactant thus greatly reduces surface tension , increasing compliance allowing the lung to inflate much more easily, thereby reducing the work of breathing. It reduces the pressure difference needed to allow the lung to inflate. The lung's compliance, and ventilation decrease when lung tissue becomes diseased and fibrotic. As the alveoli increase in size, the surfactant becomes more spread out over the surface of the liquid. This increases surface tension effectively slowing the rate of expansion of the alveoli. This also helps all alveoli in the lungs expand at the same rate, as one that expands more quickly will experience a large rise in surface tension slowing its rate of expansion.

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Dipalmitoylphosphatidylcholine DPPC is a phospholipid and a lecithin consisting of two C 16 palmitic acid groups attached to a phosphatidylcholine head-group. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing. It also plays an important role in the study of liposomes and human bilayers. Lung surfactant LS is a surface-active material produced by most air-breathing animals for the purpose of reducing the surface tension of the water layer where gas exchange occurs in the lungs, given that the movements due to inhalation and exhalation may cause damage if there is not enough energy to sustain alveolar structural integrity. While DPPC itself already has the ability to reduce the surface tension of the alveolar liquid, the proteins and other lipids in the surfactant further facilitate the adsorption of oxygen into the air-liquid interface. DPPC is a variant of phosphatidylcholine.

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Dppc full form

The most important component of pulmonary surfactant is dipalmitoyl phosphatidylcholine, or DPPC. At the end of an expiration, when the surfactant film is maximally compressed, DPPC is probably almost the sole component in the monomolecular film, but, during inspiration, as the film expands, other elements move in. They may be phospholipids with different fatty acids, saturated or unsaturated, or with the alcohol choline replaced with ethanolamine, inositol, glycerol or serine. The elements moving into the expanding film may also be free fatty acids, di- or triglycerides, etc. The synthesis of DPPC, similar to that of other phospholipids, has been thoroughly studied and is reviewed. The building blocks, glycerol, palmitic acid, choline and phosphate, are generally produced in the lung itself, but choline is generously supplied with the bloodstream.

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The spectra in Fig. As a result, small perturbations resulting from interaction with the protein components of the mixture are more apparent. CAS Number. Curstedt, T. Drikamer, and B. Biophysical Journal. Data shown are representative of three independent experiments. Rate it:. The earlier study did, however, show a substantial effect on bilayer motions detectable through quadrupole echo decay and it was suggested that because of its size, the interaction of SP-A with the bilayer surface might be distributed over large numbers of lipids. Accepted Nov Harris, and K. Retrieved

Federal government websites often end in. The site is secure. Phosphatidylcholine PC is the major phospholipid of pulmonary surfactant and it is hypothesized that PC and its subspecies modulate the functions of alveolar macrophages.

This also explains why the compliance is greater during expiration than during inspiration. Quantitative analysis of phospholipids by HPLC with a light scattering evaporating detector — application to raw materials for cosmetic use. Journal of Physics D: Applied Physics. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant. Smith, P. Kevin M. In order to determine the effects of a period of incubation on productions of ROIs, preincubation of cells with lipids was performed using the optimal dose of lipid as determined by the previous experiment. Address reprint requests to M. Immunomodulatory functions of surfactant. Figueres A, Raetz C.