Cd11b

Blood ; 18 : — A consistently increased cd11b expression of the adhesion receptor CD11b is a hallmark of the reported genomewide gene expression changes in precursor B-cell acute lymphoblastic leukemia PBC-ALL after 1 week of induction therapy, cd11b.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The development of easily accessible tools for human immunophenotyping to classify patients into discrete disease endotypes is advancing personalized therapy. However, no systematic approach has been developed for the study of inflammatory lung diseases with often complex and highly heterogeneous disease etiologies.

Cd11b

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing and tumor progression. Recruitment of these cells is regulated by integrins, a family of adhesion receptors that includes integrin CD11b. Here we report that, unexpectedly, integrin CD11b does not regulate myeloid cell recruitment to tumors but instead controls myeloid cell polarization and tumor growth. CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a. In contrast, inhibition of CD11b prevents Let7a expression and induces cMyc expression, leading to immune suppressive macrophage polarization, vascular maturation, and accelerated tumor growth. Pharmacological activation of CD11b with a small molecule agonist, Leukadherin 1 LA1 , promotes pro-inflammatory macrophage polarization and suppresses tumor growth in animal models of murine and human cancer.

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In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus , with an odds ratio of 1. In histopathology , immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia. CD11b, as an integrin molecule on the surface of leukocytes , plays an important role in cell migration, adhesion, and transmigration across blood vessels , because it can bind to components of extracellular matrix and intracellular adhesion molecules ICAMs on the endothelial surface. This process is important for leukocyte recruitment into the site of inflammation. Moreover, there are other important processes with CD11b involvement, more precisely Mac-1 integrin involvement as a whole.

Blood ; 18 : — A consistently increased mRNA expression of the adhesion receptor CD11b is a hallmark of the reported genomewide gene expression changes in precursor B-cell acute lymphoblastic leukemia PBC-ALL after 1 week of induction therapy. To investigate its clinical relevance, CD11b protein expression in leukemic blasts has been prospectively measured at diagnosis patients and during therapy 53 patients. CD11b positivity conferred a 5-fold increased risk of minimal residual disease MRD after induction therapy day 33 and of high-risk group assignment after consolidation therapy day In the multivariate analysis CD11b expression was an independent prognostic factor compared with other clinically relevant parameters at diagnosis. Microarray-based gene expression profiling is a powerful tool for basic research, target discovery, and identification of novel molecular biomarkers. In view of its crucial clinical significance, MRD assessment has become central to the clinical management of patients with ALL. ALL cells differ from normal lymphoid precursors by quantitative aberrations in their tissue-, differentiation-, and cytogenetic-associated antigenic expression profiles. We directly addressed this issue by comparing genome-wide gene expression analysis of leukemic blast cells at diagnosis and after 7 days of induction therapy with prednisolone. These changes collectively indicated an expression shift in day 8 d8 cells toward resting mature B cells.

Cd11b

Erbo Christensen, S. Pravsgaard Christensen, A. Based on their activation state T cells can be subdivided into naive, effector and memory subsets. Naive T cells are resting cells that have not yet encountered antigen, whereas effector T cells are recently activated cells able to perform specialized functions with high efficiency and without further differentiation. Immunological memory is the capacity of the immune system to respond faster and more efficiently against an antigen previously encountered by the host 1. The mechanisms underlying the accelerated secondary response appear to be both an increased number of antigen-specific T cells and a qualitative change in T cells that have already been primed by antigen contact 2 — 5. Although functional assays to detect the effects of antigenic priming are well established, it has been difficult to identify memory T cells in phenotypic terms. One reason for this has been an inability to distinguish between recently activated effector T cells and memory T cells, as many cell-surface markers are shared between these two functionally distinct subsets 6 — 9. It functions in cellular adhesion, phagocytosis and extravasation, and it may play a role in chemotaxis 9 ,

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These data could explain why CD11b-deficient mice exhibited exaggerated inflammatory responses against the MRSA infection. Submit Cancel. ALL cells differ from normal lymphoid precursors by quantitative aberrations in their tissue-, differentiation-, and cytogenetic-associated antigenic expression profiles. The Han et al. The number of migratory cells was counted from random microscopic fields for each sample. Cancer Cell 19 , — The Korean Association of Immunologists. Ethics declarations Competing interests Vineet Gupta is founder of Adhaere Pharmaceuticals, a biotechnology company developing LA1 for therapeutic indications. Integrins: a family of cell surface receptors. Clinically, CD11b mRNA levels correlated significantly with the cytoreduction rate after the first week of the therapy.

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Integrin-dependent phagocytosis: spreading from microadhesion to new concepts. Immunol Today 16 7 — Mammalian protein found in Homo sapiens. The Han et al. Eur J Immunol 9 4 —6. Structure and function of adhesion receptors in leukocyte trafficking. A comprehensive analysis of shared loci between systemic lupus erythematosus SLE and sixteen autoimmune diseases reveals limited genetic overlap. Distinct inflammatory signatures appear in mouse chronic obstructive pulmonary disease models of acute lung exacerbations. Latest Issue Alert. In most cases the latter possibility cannot be excluded, because the absolute number of blasts, which is usually high at diagnosis, dramatically decreases during therapy. Roush, S. The pathogenesis of sepsis. However, no systematic approach has been developed for the study of inflammatory lung diseases with often complex and highly heterogeneous disease etiologies. To determine the role of macrophage CD11b activation in tumor growth, we performed adoptive transfer of LA1 treated macrophages; LA1 treated macrophages directly and robustly inhibited tumor growth. Barry Dmitry I.