Balzac plus

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Last updated on Balzak plus is indicated in adult patients whose blood pressure is not adequately controlled on the combination of olmesartan medoxomil and amlodipine taken as dual-component formulation. Balzak plus is indicated as substitution therapy in adult patients whose blood pressure is adequately controlled on the combination of olmesartan medoxomil, amlodipine and hydrochlorothiazide, taken as a dual-component olmesartan medoxomil and amlodipine or olmesartan medoxomil and hydrochlorothiazide and a single-component formulation hydrochlorothiazide or amlodipine. A step-wise titration of the dosage of the individual components is recommended before changing to the triple-component combination. When clinically appropriate, direct change from dual-component combination to the triple-component combination may be considered. Patients controlled on stable doses of olmesartan medoxomil, amlodipine and hydrochlorothiazide taken at the same time as a dual-component olmesartan medoxomil and amlodipine or olmesartan medoxomil and hydrochlorothiazide and a single-component formulation hydrochlorothiazide or amlodipine may be switched to Balzak plus containing the same component doses.

Balzac plus

Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group slow channel blocker or calcium ion antagonist and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. Olmesartan medoxomil is a potent, orally active, selective angiotensin II receptor type AT 1 antagonist. It is expected to block all actions of angiotensin II mediated by the AT 1 receptor, regardless of the source or route of synthesis of angiotensin II. The selective antagonism of the angiotensin II AT 1 receptors results in increases in plasma renin levels and angiotensin I and II concentrations, and some decrease in plasma aldosterone concentrations. Hydrochlorothiazide is a diuretic with antihypertensive properties. It acts by inhibiting the renal tubular re-absorption of sodium and chloride ions, which are excreted with an accompanying volume of water. Potassium excretion is also promoted. This drug has been classified in the anatomical therapeutic chemical ATC classification system as follows:. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles. Read about Amlodipine. Read about Olmesartan medoxomil.

Read about Olmesartan medoxomil. Balzac plus medoxomil has not been evaluated in patients with severe hepatic impairment. Max estimates.

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Tratamiento adicional. Insuficiencia renal. Balzak Plus se puede tomar con o sin alimentos. Insuficiencia renal grave ver secciones 4. Segundo y tercer trimestre del embarazo ver secciones 4. Bloqueo dual del sistema renina-angiotensina-aldosterona SRAA :. Aldosteronismo primario:. Por lo tanto, no se recomienda el uso de Balzak Plus en dichos pacientes. El tratamiento con tiazidas puede alterar la tolerancia a la glucosa. Una hipercalcemia puede ser evidencia de hiperparatiroidismo oculto.

Balzac plus

Amlodipine is a Dihydropyridine Calcium antagonist that inhibits the transmembrane influx of Calcium ions into cardiac and vascular smooth muscle. It has greater affinity towards vascular smooth muscle than on cardiac muscle. Amlodipine is peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and thereby reduces blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac oxygen demand by reducing after load.

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When pregnancy is diagnosed, treatment with angiotensin II receptor antagonists should be stopped immediately, and, if appropriate, alternative therapy should be started. Olmesartan medoxomil In chronic toxicity studies in rats and dogs, olmesartan medoxomil showed similar effects to other AT 1 receptor antagonists and ACE inhibitors: raised blood urea BUN and creatinine; reduction in heart weight; reduction of red cell parameters erythrocytes, haemoglobin, haematocrit ; histological indications of renal damage regenerative lesions of the renal epithelium, thickening of the basal membrane, dilatation of the tubules. There is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function including acute renal failure. Cases of photosensitivity reactions have been reported with thiazide diuretics. This composite cardiovascular endpoint included cardiovascular death in 10 3. Pregnancy: Angiotensin II receptor antagonists should not be initiated during pregnancy. Pharmacokinetic properties The information provided in Pharmacokinetic properties of Balzak plus is based on data of another medicine with exactly the same composition as the Balzak plus. If hypotension occurs, the patient should be placed in a supine position, with salt and volume replacements given quickly. Olmesartan medoxomil is an orally active, selective angiotensin II receptor type AT 1 antagonist. Balzac Paris. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. The study was terminated early because of an increased risk of adverse outcomes.

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Special precautions for disposal and other handling. The selective antagonism of the angiotensin II AT 1 receptors by olmesartan results in increases in plasma renin levels and angiotensin I and II concentrations, and some decrease in plasma aldosterone concentrations. However, it should be borne in mind that dizziness, headache, nausea or fatigue may occasionally occur in patients taking antihypertensive therapy and that these symptoms may impair the ability to react. In the event of overdosage with Balzak plus, treatment should be symptomatic and supportive. As for any patient receiving diuretic therapy, periodic determination of serum electrolytes should be performed at appropriate intervals. Balzak plus should therefore be administered with caution in these patients. It acts by inhibiting the renal tubular re-absorption of sodium and chloride ions, which are excreted with an accompanying volume of water. Cases of photosensitivity reactions have been reported with thiazide diuretics. The European Medicines Agency has waived the obligation to submit the results of studies with Balzak plus in all subsets of the paediatric population in essential hypertension. Log in. With hydrochlorothiazide, onset of diuresis occurs at about 2 hours and peak effect occurs at about 4 hours post-dose, whilst the action persists for approximately hours. Bestsellers Iconics. Identifier s : , , , , , BE, BE